Masuda Toshiya, Fujita Nao, Odaka Yuka, Takeda Yoshio, Yonemori Shigetomo, Nakamoto Katsuo, Kuninaga Hideki
Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770-8502, Japan.
Biosci Biotechnol Biochem. 2007 Sep;71(9):2316-20. doi: 10.1271/bbb.70249. Epub 2007 Sep 7.
The tyrosinase inhibitory activity of the extracts of 53 parts of 36 plant species cultivated for edible and medicinal use in Okinawa was investigated. The extract of Nandina domestica showed potent activity among these. The inhibitor in the extract was purified by assay-guided fractionation to give a simple phenol glucoside. Although it was a known compound (4-beta-D-glucopyranosyloxybenzoic acid), its inhibitory activity toward tyrosinase is revealed for the first time in this work.
对在冲绳种植用于食用和药用的36种植物的53个部位的提取物的酪氨酸酶抑制活性进行了研究。南天竹提取物在这些提取物中表现出较强的活性。通过分析引导分级分离法对提取物中的抑制剂进行纯化，得到一种简单的酚糖苷。尽管它是一种已知化合物（4-β-D-吡喃葡萄糖氧基苯甲酸），但其对酪氨酸酶的抑制活性在本研究中首次被揭示。
