人类辅助性T细胞17淋巴细胞会促进血脑屏障破坏和中枢神经系统炎症。
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.
作者信息
Kebir Hania, Kreymborg Katharina, Ifergan Igal, Dodelet-Devillers Aurore, Cayrol Romain, Bernard Monique, Giuliani Fabrizio, Arbour Nathalie, Becher Burkhard, Prat Alexandre
机构信息
Neuroimmunology Unit, Center for the Study of Brain Diseases, Centre Hospitalier de l'Université de Montréal-Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada.
出版信息
Nat Med. 2007 Oct;13(10):1173-5. doi: 10.1038/nm1651. Epub 2007 Sep 9.
Abstract
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.
摘要
辅助性T细胞17（T(H)17）淋巴细胞似乎在多种炎症性疾病的发病机制中起关键作用。我们在此证明了白细胞介素-17（IL-17）和白细胞介素-22（IL-22）受体在多发性硬化症病变的血脑屏障内皮细胞（BBB-ECs）上的表达，并表明IL-17和IL-22在体外和体内均可破坏血脑屏障紧密连接。此外，T(H)17淋巴细胞可有效穿过BBB-ECs，高表达颗粒酶B，杀死人类神经元，并通过募集CD4+淋巴细胞促进中枢神经系统炎症。
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