Boriani G, Strocchi E, Capucci A, Callivà R, Frabetti L, Ambrosioni E, Magnani B
Institute of Cardiovascular Diseases, University of Bologna, Italy.
Eur J Clin Pharmacol. 1991;41(1):57-9. doi: 10.1007/BF00280107.
The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.
已对12例室性心律失常患者单次给药后及长期治疗期间氟卡尼的药代动力学进行了研究。长期治疗期间，半衰期和曲线下面积均显著增加。这表明，在肾功能和肝功能正常的患者中，氟卡尼的动力学也可能是非线性的。长期治疗期间血浆氟卡尼水平的升高无法预测，因此建议密切监测其血浆水平。
