• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Determination of debrisoquine and its 4-hydroxy metabolite in urine by high-performance liquid chromatography.

作者信息

Harrison P M, Tonkin A M, Dixon S T, McLean A J

出版信息

J Chromatogr. 1986 Jan 10;374(1):204-8. doi: 10.1016/s0378-4347(00)83273-9.

DOI:10.1016/s0378-4347(00)83273-9
PMID:3949931
Abstract
摘要

相似文献

1
Determination of debrisoquine and its 4-hydroxy metabolite in urine by high-performance liquid chromatography.高效液相色谱法测定尿中异喹胍及其4-羟基代谢物
J Chromatogr. 1986 Jan 10;374(1):204-8. doi: 10.1016/s0378-4347(00)83273-9.
2
Liquid chromatographic method for the determination of debrisoquine and its 4-hydroxy metabolite in human urine.液相色谱法测定人尿中异喹胍及其4-羟基代谢物
J Chromatogr. 1986 Jun 13;378(2):509-13. doi: 10.1016/s0378-4347(00)80752-5.
3
High-performance liquid chromatographic method for the analysis of debrisoquine and its S-(+)- and R-(-)-hydroxy metabolites in urine.高效液相色谱法分析尿液中的异喹胍及其S-(+)-和R-(-)-羟基代谢物。
J Chromatogr. 1987 Dec 25;423:344-50. doi: 10.1016/0378-4347(87)80362-6.
4
Direct determination of debrisoquine and 4-hydroxydebrisoquine using a high-performance liquid chromatographic switching technique.使用高效液相色谱切换技术直接测定去甲丙咪嗪和4-羟基去甲丙咪嗪。
J Chromatogr. 1987 Aug 7;419:469-74. doi: 10.1016/0378-4347(87)80318-3.
5
Assay of debrisoquine and 4-hydroxydebrisoquine in urine by reversed-phase high-performance liquid chromatography using on-line sample clean-up on a standard isocratic chromatograph.使用标准等度色谱仪上的在线样品净化，通过反相高效液相色谱法测定尿液中的异喹胍和4-羟基异喹胍。
J Chromatogr. 1988 Jun 24;428(1):178-82. doi: 10.1016/s0378-4347(00)83905-5.
6
Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection.采用气相色谱-火焰离子化和氮选择性检测法测定生物流体中的异喹胍及其4-羟基代谢物。
J Chromatogr. 1977 Mar 11;133(1):161-6. doi: 10.1016/s0021-9673(00)89216-x.
7
Rapid liquid chromatographic determination of debrisoquine and its hydroxy metabolite in human urine to define hydroxylation phenotypes.快速液相色谱法测定人尿中去甲异喹胍及其羟基代谢物以确定羟基化表型。
J Chromatogr. 1987 Dec 25;423:340-3. doi: 10.1016/0378-4347(87)80361-4.
8
The effect of urine pH on debrisoquine phenotyping: application of an HPLC-method.尿液pH值对异喹胍表型分析的影响：高效液相色谱法的应用
Int J Clin Pharmacol Ther Toxicol. 1990 May;28(5):223-6.
9
Liquid chromatographic assay for debrisoquine and 4-hydroxydebrisoquine in urine.尿液中去甲丙咪嗪和4-羟基去甲丙咪嗪的液相色谱测定法。
J Chromatogr. 1986 Jan 10;374(1):200-3. doi: 10.1016/s0378-4347(00)83272-7.
10
Rapid high-performance liquid chromatographic method for determination of debrisoquine and 4-hydroxy-debrisoquine in urine for CYP2D6 phenotyping.用于CYP2D6表型分析的尿液中去甲丙咪嗪和4-羟基去甲丙咪嗪的快速高效液相色谱测定法。
Pharmacogenetics. 1999 Aug;9(4):529-31.

引用本文的文献

1
Debrisoquine hydroxylation in a Polish population.
Eur J Clin Pharmacol. 1995;47(6):503-5. doi: 10.1007/BF00193702.
2
Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population.日本人群中三种测试探针（美托洛尔、异喹胍和司巴丁）代谢率之间与遗传决定的氧化多态性的相关性。
Br J Clin Pharmacol. 1990 Jan;29(1):111-5. doi: 10.1111/j.1365-2125.1990.tb03609.x.
3
Minimal effective concentration values of propafenone and 5-hydroxy-propafenone in acute and chronic therapy.
Cardiovasc Drugs Ther. 1990 Feb;4(1):281-7. doi: 10.1007/BF01857646.
4
The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates.以安替比林、三甲双酮和异喹胍作为模型底物，研究地尔硫䓬对人体肝脏药物代谢酶的影响。
Br J Clin Pharmacol. 1991 Mar;31(3):353-5. doi: 10.1111/j.1365-2125.1991.tb05543.x.
5
Metabolism of debrisoquine and susceptibility to breast cancer.异喹胍代谢与乳腺癌易感性
Breast Cancer Res Treat. 1991 Mar;18(1):43-8. doi: 10.1007/BF01975442.
6
Flecainide: evidence of non-linear kinetics.氟卡尼：非线性动力学证据。
Eur J Clin Pharmacol. 1991;41(1):57-9. doi: 10.1007/BF00280107.