日本血管疾病患者血清蛋白的多态性。I. 原发性静脉曲张中的因子 XIIIB、纤溶酶原和补体类型。

Polymorphisms of serum proteins in Japanese patients with vascular diseases. I. Factor XIIIB, plasminogen and complement types in primary varicose veins.

作者信息

Mizutani K, Nishimukai H, Yasugi T, Iwahashi K, Tsunekawa K, Shinomiya T

机构信息

First Department of Surgery, School of Medicine, Ehime University, Japan.

出版信息

Hum Hered. 1991;41(4):270-5. doi: 10.1159/000154011.

DOI:10.1159/000154011

PMID:1783414

Abstract

The polymorphisms of the B subunit of coagulation factor XIII (F13B), plasminogen (PLG), complement C6, C7, factor B (BF) and factor I (IF) were studied among 21 unrelated Japanese patients with primary varicose veins (PVV) by isoelectric focusing followed by immunoblotting. The allele frequencies for F13B2 and IFA in PVV patients were significantly higher (F13B2, p = 0.0047; IFA, p = 0.0006) than those in healthy controls (n = 60). Significant associations of F13B 2 allotype [p = 0.0220, relative risk (RR) = 13.9] and IF A allotype (p = 0.0006, RR = 10.0) with PVV were observed; however, no significant association of PLG, C6, C7 or BF allotype with the disease was found.

摘要

采用等电聚焦继以免疫印迹法，对21例无亲缘关系的日本原发性静脉曲张（PVV）患者的凝血因子XIII（F13B）B亚基、纤溶酶原（PLG）、补体C6、C7、B因子（BF）和I因子（IF）的多态性进行了研究。PVV患者中F13B2和IFA的等位基因频率显著高于健康对照者（n = 60）（F13B2，p = 0.0047；IFA，p = 0.0006）。观察到F13B 2同种异型（p = 0.0220，相对危险度RR = 13.9）和IF A同种异型（p = 0.0006，RR = 10.0）与PVV有显著关联；然而，未发现PLG、C6、C7或BF同种异型与该疾病有显著关联。