中年肥胖黑人女性的血浆维生素B6同类物以及血浆和尿液中4-吡哆酸的浓度

Plasma B6 vitamer and plasma and urinary 4-pyridoxic acid concentrations of middle-aged obese black women.

作者信息

Driskell J A, Chrisley B M, Reynolds L K, Moak S W

机构信息

Department of Human Nutrition and Foods, Virginia Polytechnic Institute and State University, Blacksburg 24061.

出版信息

J Chromatogr. 1991 Aug 23;568(2):333-40. doi: 10.1016/0378-4347(91)80171-8.

DOI:10.1016/0378-4347(91)80171-8

PMID:1783639

Abstract

Plasma B6 vitamer and plasma and urinary 4-pyridoxic acid (4-PA) concentrations of fifteen middle-aged obese black women were determined by high-performance liquid chromatography (HPLC). Estimated protein and vitamin B6 intakes of the subjects, aged 27-52 years, were 64.5 +/- 15.6 g and 1.21 +/- 0.68 mg (mean +/- S.D.), respectively. Mean HPLC-derived plasma B6 vitamer and 4-PA concentrations for these subjects were 68.9, 3.1, 1.2, 4.1, 3.4, 7.2 and 2.0 nmol/l for pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal, pyridoxine, pyridoxamine and 4-PA, respectively. The mean urinary 4-PA/creatinine ratio of the women was 0.88 mumol/mmol. All subjects had plasma PLP levels indicative of adequate vitamin B6 status. Vitamin B6 status parameters of the middle-aged obese black women were similar to those previously reported for white nonobese women having adequate vitamin B6 status.

摘要

采用高效液相色谱法（HPLC）测定了15名中年肥胖黑人女性的血浆维生素B6相关化合物以及血浆和尿液中4-吡哆酸（4-PA）的浓度。这些年龄在27至52岁之间的受试者，估计蛋白质摄入量和维生素B6摄入量分别为64.5±15.6克和1.21±0.68毫克（均值±标准差）。这些受试者通过HPLC得出的血浆维生素B6相关化合物和4-PA的平均浓度，吡哆醛5'-磷酸（PLP）、吡哆醇5'-磷酸、吡哆胺5'-磷酸、吡哆醛、吡哆醇、吡哆胺和4-PA分别为68.9、3.1、1.2、4.1、3.4、7.2和2.0纳摩尔/升。这些女性的尿4-PA/肌酐平均比值为0.88微摩尔/毫摩尔。所有受试者的血浆PLP水平均表明维生素B6状态充足。中年肥胖黑人女性的维生素B6状态参数与先前报道的维生素B6状态充足的非肥胖白人女性相似。