Osato K, Katsukawa C, Makino M
Osaka Prefectural Bandai Clinic for STD.
Jpn J Antibiot. 1991 Nov;44(11):1206-10.
Results of the treatment of 5 cases of males with uncomplicated gonoccocal urethritis using levofloxacin (LVFX, DR-3355), the L-type optical isomer of ofloxacin (OFLX), were compared with those treated with OFLX itself. Three hundred mg/day of LVFX or 600 mg/day of OFLX was given to each patient for 5 days. Both drugs showed excellent clinical results in all the patients. When MICs of the 2 drugs were compared against 57 isolated strains of Neisseria gonorrhoeae including 3 penicillinase-producing N. gonorrhoeae, it was found that MICs of LVFX were approximately one half of those of OFLX.
对5例男性单纯性淋菌性尿道炎患者使用左氧氟沙星（LVFX，DR - 3355），即氧氟沙星（OFLX）的L型光学异构体进行治疗，并与使用OFLX本身治疗的效果进行比较。每位患者每天服用300mg的LVFX或600mg的OFLX，持续5天。两种药物在所有患者中均显示出优异的临床效果。当将这两种药物针对57株淋病奈瑟菌分离株（包括3株产青霉素酶的淋病奈瑟菌）的最低抑菌浓度（MIC）进行比较时，发现LVFX的MIC约为OFLX的一半。
