Janaszek W
Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Med Dosw Mikrobiol. 1991;43(1-2):43-9.
The degree of thermal degradation of BCG vaccines prepared from various substrains, using a test evaluating number of viable particles of BCG was determined. Thermal degradation coefficient were established for particular vaccines in different temperatures and a prognosis time curve of 50% CFU titer loss was constructed. It was found, that polish vaccine does not differ essentially from danish and french vaccines in respect to thermostability. Japanese preparation showed higher stability in all temperatures tested as compared to above mentioned vaccines. It was shown that when based on presented figures, and using interpolation method, it is possible with a high degree of probability foresee a decrease of vaccine titer at optional temperature.
使用评估卡介苗活颗粒数量的试验，测定了由各种亚菌株制备的卡介苗的热降解程度。确定了特定疫苗在不同温度下的热降解系数，并构建了50% 菌落形成单位效价损失的预后时间曲线。结果发现，波兰疫苗在热稳定性方面与丹麦和法国疫苗没有本质区别。与上述疫苗相比，日本制剂在所有测试温度下都表现出更高的稳定性。结果表明，根据给出的数据并使用插值法，很有可能在任意温度下预测疫苗效价的下降。
