Rodriguez A B, Barriga C, de la Fuente M
Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.
Microbiol Immunol. 1991;35(7):545-56. doi: 10.1111/j.1348-0421.1991.tb01585.x.
Interactions between antimicrobial agents and phagocytic cells, especially neutrophils, have a potential role in the treatment of infections. The in vitro effects of cefmetazole, a novel beta-lactam antibiotic, at a therapeutic concentration reached in plasma (50 micrograms/ml) on phagocytic and cytotoxic functions of human neutrophils have been studied. In human neutrophils, adherence capacity to nylon fiber and to substrate, chemotaxis, attachment to and ingestion of Candida albicans (with serum, with decomplemented serum and without serum), ingestion of inert particles (latex beads), candidicidal activity and superoxide anion production were all stimulated by cefmetazole. Cefmetazole at this dose was a chemotactic agent for neutrophils. Antibody-dependent cellular cytotoxicity (ADCC) was also increased by this anti-microbial agent.
抗菌剂与吞噬细胞（尤其是中性粒细胞）之间的相互作用在感染治疗中具有潜在作用。我们研究了新型β-内酰胺抗生素头孢美唑在血浆中达到的治疗浓度（50微克/毫升）对人中性粒细胞吞噬和细胞毒性功能的体外作用。在人中性粒细胞中，头孢美唑可刺激其对尼龙纤维和底物的黏附能力、趋化性、对白色念珠菌的附着和吞噬（有血清、无补体血清和无血清条件下）、对惰性颗粒（乳胶珠）的吞噬、杀念珠菌活性以及超氧阴离子的产生。该剂量的头孢美唑是中性粒细胞的趋化剂。这种抗菌剂还增强了抗体依赖性细胞毒性（ADCC）。
