Feldman D
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3710-3. doi: 10.1073/pnas.73.10.3710.
Previous studies suggested a possible association between C-type virus particle formation and erythropoiesis. In this experiment, normal C3Hf mice were injected with erythropoietin in order to increase the rate of erythropoiesis. Sections of spleen from these animals revealed extensive areas of erythroblasts. C-type particles, budding from erythroblasts, were often observed in such areas of spleen from every mouse injected with erythropoietin. In contrast, in sections of spleen from control mice, zones of erythropoiesis were limited, and only a few scattered C-type virus particles were observed in some of the animals examined.
先前的研究表明C型病毒颗粒的形成与红细胞生成之间可能存在关联。在本实验中，给正常的C3Hf小鼠注射促红细胞生成素以提高红细胞生成率。这些动物脾脏切片显示有广泛的成红细胞区域。在每只注射促红细胞生成素的小鼠的脾脏此类区域中，经常观察到从成红细胞中芽生的C型颗粒。相比之下，在对照小鼠的脾脏切片中，红细胞生成区域有限，并且在一些检查的动物中仅观察到少数散在的C型病毒颗粒。
