一种用于构建新型稠合和桥连三唑的三唑导向闭环复分解反应。
A triazole-templated ring-closing metathesis for constructing novel fused and bridged triazoles.
作者信息
Zhang Xuejun, Hsung Richard P, Li Hongyan
机构信息
Division of Pharmaceutical Sciences and Department of Chemistry, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705-2222, USA.
出版信息
Chem Commun (Camb). 2007 Jun 21(23):2420-2. doi: 10.1039/b701040k.
The feasibility of trapping the vinyl copper intermediate generated in situ from azide-[3 + 2] cycloadditions and viability of employing these triazoles as unique templates for ring-closing metathesis are described here; this work effectively combines the two powerful reactions for the first time to construct various de novo fused and bridged triazoles that are otherwise not trivial to synthesize.
本文描述了捕获由叠氮化物-[3 + 2]环加成原位生成的乙烯基铜中间体的可行性，以及将这些三唑用作闭环复分解独特模板的可行性；这项工作首次有效地将这两种强大的反应结合起来，以构建各种从头合成的稠合和桥连三唑，否则这些三唑的合成并非易事。
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