Sica Antonio, Rubino Luca, Mancino Alessandra, Larghi Paola, Porta Chiara, Rimoldi Monica, Solinas Graziella, Locati Massimo, Allavena Paola, Mantovani Alberto
Department of Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy.
Expert Opin Ther Targets. 2007 Sep;11(9):1219-29. doi: 10.1517/14728222.11.9.1219.
Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.
临床和实验证据表明，肿瘤中存在的主要白细胞群体，即所谓的肿瘤相关巨噬细胞（TAM），是支持肿瘤生长的白细胞浸润的主要成分。多年来，支持TAM促肿瘤功能的机制越来越清晰，在多个实验性肿瘤模型中，炎症反应（最常见由巨噬细胞介导）的激活已被证明对肿瘤的完全转化和进展起着至关重要的作用。这一证据有力地支持了TAM是肿瘤微环境中表达的炎症网络的核心协调者这一观点，并表明这些细胞可能是抗癌治疗的靶点。
