Simmons Ashley, Rouf Emran, Whittle Jeff
Division of General and Geriatric Medicine, University of Kansas Medical Center, Mail stop 1020, Wescoe 5026, 3901 Rainbow Boulevard, Kansas, KS 66160, USA.
J Gen Intern Med. 2007 Nov;22(11):1613-6. doi: 10.1007/s11606-007-0280-7. Epub 2007 Sep 11.
The constellation of chronic cough, dyspnea, and hemoptysis can include a broad range of differential diagnoses. Although uncommon, exogenous lipoid pneumonia (ELP) should be considered when patients present with this symptom complex. We report a case of a 72-year-old female who presented with hemoptysis, cough, and dyspnea. The admission computed tomography scan of the chest revealed progressive interstitial infiltrates. Bronchoscopy revealed diffuse erythema without bleeding. Culture and cytology of lavage fluid were negative. Open-lung biopsy revealed numerous lipid-laden macrophages and multinucleated foreign-body giant cells. On further questioning, the patient admitted to the daily use of mineral oil for constipation. The diagnosis of ELP was made. The literature review revealed that many cases typically present with chronic cough with or without dyspnea. Our case illustrates an unusual presenting symptom of hemoptysis and the need to identify patients who can be at risk of developing this rare condition.
慢性咳嗽、呼吸困难和咯血这一组症状可能包含多种不同的诊断。虽然外源性类脂性肺炎(ELP)并不常见,但当患者出现这种症状组合时应予以考虑。我们报告一例72岁女性患者,她出现咯血、咳嗽和呼吸困难。入院时胸部计算机断层扫描显示进行性间质浸润。支气管镜检查显示弥漫性红斑但无出血。灌洗液培养和细胞学检查均为阴性。开胸肺活检显示大量充满脂质的巨噬细胞和多核异物巨细胞。进一步询问时,患者承认因便秘每天使用矿物油。诊断为ELP。文献回顾显示,许多病例通常表现为伴有或不伴有呼吸困难的慢性咳嗽。我们的病例说明了咯血这一不寻常的表现症状,以及识别可能有患这种罕见疾病风险的患者的必要性。