Henne Melinda B, Zhang Mallory, Paroski Sylvie, Kelshikar Bhagyashree, Westphal Lynn M
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
J Reprod Med. 2007 Jul;52(7):585-90.
To evaluate obstetric complications in women conceiving with donated oocytes as compared to controls of advanced maternal age.
We compared the obstetric outcomes of a cohort of 69 women who conceived through oocyte donation to all women over 38 years old (n = 681) who delivered at the same hospital in the same period. We first compared obstetric complications and outcomes in the entire cohort. Additional comparisons were made while controlling for multiple covariates: maternal and fetal complications, mode of delivery, estimated gestational age and infant weight at delivery.
Women who conceived with donor oocytes were older than controls. In the cohort, oocyte recipients were at increased risk for several obstetric complications. However, when controlling for age and multiple gestations, only preterm labor, preeclampsia and protracted labor were increased in oocyte recipients.
Women who conceive with donor oocytes might be at increased risk of complications during pregnancy. When age and multiple gestations are accounted for, these patients remain at risk for preterm labor, preeclampsia and protracted labor requiring cesarean delivery.
评估与高龄产妇对照组相比，接受捐赠卵母细胞受孕女性的产科并发症情况。
我们将一组69例通过卵母细胞捐赠受孕的女性的产科结局与同期在同一家医院分娩的所有38岁以上女性（n = 681）进行了比较。我们首先比较了整个队列中的产科并发症和结局。在控制多个协变量的情况下进行了额外比较：母婴并发症、分娩方式、估计孕周和出生时婴儿体重。
接受捐赠卵母细胞受孕的女性比对照组年龄更大。在该队列中，卵母细胞接受者发生几种产科并发症的风险增加。然而，在控制年龄和多胎妊娠后，卵母细胞接受者仅早产、先兆子痫和产程延长的发生率增加。
接受捐赠卵母细胞受孕的女性在孕期发生并发症的风险可能增加。在考虑年龄和多胎妊娠因素后，这些患者仍有早产、先兆子痫和需要剖宫产的产程延长的风险。
