魁北克铝冶炼厂工人的死亡率和癌症经历。第一部分：冶炼厂与煤焦油沥青挥发物（CTPV）暴露评估。
Mortality and cancer experience of Quebec aluminum reduction plant workers. Part I: The reduction plants and coal tar pitch volatile (CTPV) exposure assessment.
作者信息
Lavoué Jérôme, Gérin Michel, Côté Jacques, Lapointe Richard
机构信息
Groupe de Recherche Interdisciplinaire en Santé, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montréal, Québec, Canada.
出版信息
J Occup Environ Med. 2007 Sep;49(9):997-1008. doi: 10.1097/JOM.0b013e3181484cf3.
OBJECTIVES
This paper presents the exposure assessment and job-exposure matrix (JEM) used to estimate coal tar pitch volatile (CTPV) exposure for a study of mortality and cancer incidence in aluminum smelter workers in Quebec, Canada.
METHODS
Historical CTPV exposure was assessed by estimating benzene-soluble material (BSM) and benzo[a]pyrene (B[a]P) levels for combinations of job and time period. Estimates were derived by using several procedures including averaging measurement data, a deterministic mathematical model using process-related correction factors, and expert-based extrapolation.
RESULTS
The JEM comprised 28,910 jobs, covering 7 facilities from 1916 to 1999. Estimated exposures ranged from 0.01 microg/m(3) to 68.08 microg/m(3) (B[a]P) and 0.01 mg/m(3) to 3.64 mg/m(3) (BSM) and were lowest before 1940 and after 1980.
CONCLUSION
This methodology constitutes an improvement compared with methods used for previous studies of the Quebec cohort.
目的
本文介绍了在一项针对加拿大魁北克省铝冶炼工人死亡率和癌症发病率的研究中，用于估算煤焦油沥青挥发物（CTPV）暴露的暴露评估和作业暴露矩阵（JEM）。
方法
通过估算作业和时间段组合的苯溶性物质（BSM）和苯并[a]芘（B[a]P）水平来评估历史CTPV暴露。估算值通过多种程序得出，包括测量数据平均、使用与工艺相关校正因子的确定性数学模型以及基于专家的外推法。
结果
JEM包含28,910个作业，涵盖1916年至1999年的7个工厂。估算的暴露范围为0.01微克/立方米至68.08微克/立方米（B[a]P）以及0.01毫克/立方米至3.64毫克/立方米（BSM），且在1940年之前和1980年之后最低。
结论
与之前针对魁北克队列研究使用的方法相比，该方法有所改进。
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