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[银屑病性风湿病]

[Psoriatic rheumatism].

作者信息

Bardin T

机构信息

Clinique de rhumatologie, hôpital Lariboisière, 6, Paris.

出版信息

Rev Prat. 1991 Oct 15;41(22):2159-64.

PMID:1784915
Abstract

Five to seven per cent of patients with cutaneous psoriasis develop a seronegative inflammatory arthritis which is often erosive and frequently both peripheral and axial. The most common peripheral type of psoriatic arthritis is represented by asymmetrical oligoarthritis, the localisation most suggestive of psoriasis being distal interphalangeal arthritis. Symmetrical polyarthritis may also be observed. Severe and mutilating forms of the disease are fortunately rare. Te axial type of psoriatic arthritis consists of a usually bilateral sacroiliitis and/or spinal lesions which may result in ankylosing spondylitis. Most cases of psoriatic arthritis are treated with non-steroidal anti-inflammatory drugs alone and local treatments. Corticosteroid therapy must be administered with caution and restricted to the severe forms. A fairly large number of maintenance treatments for peripheral arthritis have been used, not always after controlled trials; the most commonly prescribed are gold salts, sulphasalazine and methotrexate.

摘要

5%至7%的皮肤银屑病患者会发展为血清阴性炎性关节炎,这种关节炎通常具有侵蚀性,常见于外周关节和中轴关节。银屑病关节炎最常见的外周类型表现为不对称性少关节炎,最提示银屑病的部位是远端指间关节。也可观察到对称性多关节炎。幸运的是,严重和致残型疾病较为罕见。银屑病关节炎的中轴型通常由双侧骶髂关节炎和/或脊柱病变组成,可能导致强直性脊柱炎。大多数银屑病关节炎病例仅用非甾体抗炎药和局部治疗。糖皮质激素治疗必须谨慎使用,且仅限于严重病例。已经使用了相当多的外周关节炎维持治疗方法,但并非总是经过对照试验;最常用的是金盐、柳氮磺胺吡啶和甲氨蝶呤。

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