Beani J C
Clinique dermatologique, centre hospitalier universitaire de Grenoble.
Rev Prat. 1991 Oct 15;41(22):2177-9.
PUVA has definitely proved effective in outbursts of extensive psoriasis vulgaris. Efficacy is enhanced by combination with retinoids. The pharmacokinetics of psoralen, which lead to adjustment of dosage to each case, is a concrete improvement which facilitates treatment. The side-effects of PUVA, and notably the risk of carcinogenesis, are well known and can be alleviated. UVB phototherapy, successfully used for a long time against psoriasis, has benefited from technical advances in the field of artificial sources of UV. In its conventional modality (wide UVB band), the adjunction of greasy excipients is necessary for efficacy. SUP and narrow-band phototherapy (311 nm lamp), more recently developed, are of considerable interest but ought to be further evaluated.
补骨脂素加紫外线A（PUVA）已被明确证明对泛发性寻常型银屑病的发作有效。与维甲酸联合使用可增强疗效。补骨脂素的药代动力学可根据具体情况调整剂量，这是一项切实的改进，有助于治疗。PUVA的副作用，尤其是致癌风险，是众所周知的，并且可以得到缓解。紫外线B（UVB）光疗长期以来成功用于治疗银屑病，受益于紫外线人工光源领域的技术进步。在其传统模式（宽UVB波段）中，为了达到疗效需要添加油性赋形剂。最近开发的超紫外线光疗（SUP）和窄带光疗（311纳米灯）很有意义，但仍需进一步评估。
