De Muynck Cassandra, Pereira Catarina S S, Naessens Myriam, Parmentier Sofie, Soetaert Wim, Vandamme Erick J
Laboratory of Industrial Microbiology and Biocatalysis, Department of Biochemical and Microbial Technology, Faculty of Bioscience Engineering, Ghent University, Gent, Belgium.
Crit Rev Biotechnol. 2007 Jul-Sep;27(3):147-71. doi: 10.1080/07388550701503584.
The genus Gluconobacter comprises some of the most frequently used microorganisms when it comes to biotechnological applications. Not only has it been involved in "historical" production processes, such as vinegar production, but in the last decades many bioconversion routes for special and rare sugars involving Gluconobacter have been developed. Among the most recent are the biotransformations involved in the production of L-ribose and miglitol, both very promising pharmaceutical lead molecules. Most of these processes make use of Gluconobacter's membrane-bound polyol dehydrogenases. However, recently other enzymes have also caught the eye of industrial biotechnology. Among them are dextran dextrinase, capable of transglucosylating substrate molecules, and intracellular NAD-dependent polyol dehydrogenases, of interest for co-enzyme regeneration. As such, Gluconobacter is an important industrial microbial strain, but it also finds use in other fields of biotechnology, such as biosensor-technology. This review aims to give an overview of the myriad of applications for Gluconobacter, with a special focus on some recent developments.
就生物技术应用而言，葡糖杆菌属包含一些最常用的微生物。它不仅参与了诸如醋生产等“历史悠久”的生产过程，而且在过去几十年中，已经开发出了许多涉及葡糖杆菌的特殊和稀有糖的生物转化途径。其中最新的是参与L-核糖和米格列醇生产的生物转化，这两种都是非常有前景的药物先导分子。这些过程大多利用了葡糖杆菌的膜结合多元醇脱氢酶。然而，最近其他酶也引起了工业生物技术的关注。其中包括能够对底物分子进行转葡糖基化的葡聚糖糊精酶，以及对辅酶再生有意义的细胞内NAD依赖性多元醇脱氢酶。因此，葡糖杆菌是一种重要的工业微生物菌株，但它也在生物技术的其他领域有应用，如生物传感器技术。本综述旨在概述葡糖杆菌的众多应用，并特别关注一些最新进展。
