Ivanova Veneta, Kolarova Mariana, Aleksieva Krasja, Dornberger Klaus-Juergen, Haertl Albert, Moellmann Ute, Dahse Hans-Martin, Chipev Nesho
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Prep Biochem Biotechnol. 2007;37(4):343-52. doi: 10.1080/10826060701593241.
Sanionins A (1) and B (2) were isolated from the moss Sanionia georgico-uncinata, collected on the Antarctic Livingston Island. The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography, and preparative HPLC, consecutively. The structures of the both compounds were elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. These compounds showed activity against important Gram-positive pathogens, such as mycobacteria, multiresistant staphylococci, and vancomycin resistant enterococci. This activity is combined with antiinflammatoric activity and low cytotoxicity.
从南极利文斯顿岛采集的苔藓乔治亚-钩叶藓中分离出了萨尼宁A（1）和B（2）。化合物1和2依次通过溶剂萃取、硅胶柱色谱和制备型高效液相色谱进行纯化。通过一维和二维核磁共振实验以及质谱研究阐明了这两种化合物的结构。这些化合物对重要的革兰氏阳性病原体具有活性，如分枝杆菌、多重耐药葡萄球菌和耐万古霉素肠球菌。这种活性与抗炎活性和低细胞毒性相结合。
