López-Labady Jeaneth, Villarroel-Dorrego Mariana, González Nieves, Pérez Ricardo, Mata de Henning Magdalena
Dental School, Universidad Central de Venezuela, Caracas, Venezuela.
J Oral Pathol Med. 2007 Oct;36(9):524-7. doi: 10.1111/j.1600-0714.2007.00569.x.
The aim of this study was to characterize oral lesions in patients with systemic and cutaneous lupus erythematosus (LE) in a Venezuelan group.
Ninety patients with LE were studied. Oral biopsies were taken from patients who showed oral mucosal involvement. Tissue samples were investigated with histology and direct immunofluorescence techniques for the presence of immunoglobulins G, M, A and complement factor C3.
In 90 patients with LE, 10 patients showed oral lesions related to the disease. Sixteen lesions were investigated. Oral ulcerations accompanied by white irradiating striae occurred in five patients, erythema was observed in five patients and a white homogeneous plaque in one patient. Fifteen lesions demonstrated vacuolar basal degeneration and 12 thickening of the basement membrane histologically. Direct immunofluorescence was negative in three samples.
These findings corroborated that ulcers are not the only manifestation of LE in the oral mucosa. Clinical and histological examinations are significant as immunoproteins are not always found on the oral sample.
本研究旨在对委内瑞拉一组系统性和皮肤型红斑狼疮（LE）患者的口腔病变特征进行描述。
对90例LE患者进行了研究。对有口腔黏膜受累表现的患者进行口腔活检。采用组织学和直接免疫荧光技术对组织样本进行研究，以检测免疫球蛋白G、M、A和补体因子C3的存在情况。
在90例LE患者中，10例出现与疾病相关的口腔病变。对16处病变进行了研究。5例患者出现伴有白色放射状条纹的口腔溃疡，5例患者出现红斑，1例患者出现白色均质斑块。组织学检查显示，15处病变呈现基底细胞空泡变性，12处病变显示基底膜增厚。3份样本的直接免疫荧光检查结果为阴性。
这些发现证实溃疡并非LE在口腔黏膜的唯一表现形式。由于在口腔样本中并非总能检测到免疫蛋白，因此临床和组织学检查具有重要意义。
