右旋糖酐70调节体外循环后的炎症反应：一种新方法的潜力？
Dextran-70 to modulate inflammatory response after cardiopulmonary bypass: potential for a novel approach?
作者信息
Schuerholz Tobias, Marx Gernot
出版信息
Crit Care. 2007;11(5):163. doi: 10.1186/cc6103.
Abstract
Potential deleterious effects of cardiopulmonary bypass (CPB) and cardioplegic cardiac arrest are known to influence outcome. The inflammatory response after CPB may have unfavourable effects especially in high-risk patients, for example, the very elderly. Thus, to blunt the release of pro-inflammatory mediators seems to be a promising approach. So far, numerous attempts at immune modulation have been performed. However, the management of cardiac surgery patients needs further improvement. In this context, Gombocz and colleagues investigated the potential anti-inflammatory effect of dextran-70. Their results suggest that compared to gelatine, dextran-70 reduces the inflammatory response in patients after CPB.
摘要
已知体外循环（CPB）和心脏停搏液诱导的心脏停搏的潜在有害影响会影响预后。CPB后的炎症反应可能产生不利影响，尤其是在高危患者中，例如高龄患者。因此，抑制促炎介质的释放似乎是一种有前景的方法。到目前为止，已经进行了许多免疫调节尝试。然而，心脏手术患者的管理仍需进一步改进。在此背景下，贡博茨及其同事研究了右旋糖酐70的潜在抗炎作用。他们的结果表明，与明胶相比，右旋糖酐70可减轻CPB术后患者的炎症反应。
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