Tian Bing-jun, Wu Yan, Zhang Dong-hua, He Li-fang, Ding Zheng-rong, Lu Lin
Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Apr;28(4):346-9.
This report presented an overview on the epidemiology of enterovirus in Yunnan province, the People's Republic of China.
A total of 210 strains of non-polioviruses isolated under acute flaccid paralysis surveillance during a 5-year study period from 1997 to 2000 and 2004 were examined. Of the 210 non-polioviruses strains, a total of 12 strains of adenoviruses were serologically identified. The remaining 198 isolates were used for molecular typing, and the viral genomes of 195 nonpolio enteroviruses (NPEVs) were translated to corresponding amino acid sequences and compared with those of the prototype strains.
Based on molecular typing, 5 isolates were classified into 5 serotypes of human enterovirus A species while 158 isolates into 34 serotypes of B and 32 isolates into 6 serotypes of C species. However, we did not isolate any viruses which belonged to human enterovirus D species. Thus, under acute flaccid paralysis surveillance, human enterovirus B species accounted for 75.2% of the 210 isolates and was considered as the predominant one, followed by human enterovirus C (12.2%), adenovirus (5.7%), and human enterovirus A (2.4%).
Although the epidemiological characteristics of NPEVs from Yunnan province remained "unknown", the molecular typing method had provided us a breakthrough to understand the epidemiology of these viruses.
本报告概述了中华人民共和国云南省肠道病毒的流行病学情况。
对1997年至2000年以及2004年为期5年的急性弛缓性麻痹监测期间分离出的210株非脊髓灰质炎病毒进行检测。在这210株非脊髓灰质炎病毒株中，通过血清学方法鉴定出12株腺病毒。其余198株分离株用于分子分型，将195株非脊髓灰质炎肠道病毒（NPEV）的病毒基因组翻译为相应的氨基酸序列，并与原型株进行比较。
基于分子分型，5株分离株被归类为人肠道病毒A种的5个血清型，158株分离株被归类为人肠道病毒B种的34个血清型，32株分离株被归类为人肠道病毒C种的6个血清型。然而，我们未分离出属于人肠道病毒D种的任何病毒。因此，在急性弛缓性麻痹监测中，人肠道病毒B种占210株分离株的75.2%，被认为是主要类型，其次是人肠道病毒C（12.2%）、腺病毒（5.7%）和人肠道病毒A（2.4%）。
尽管云南省非脊髓灰质炎肠道病毒的流行病学特征仍“不明”，但分子分型方法为我们了解这些病毒的流行病学提供了一个突破口。
