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腰椎后外侧融合术的积极效果在长期随访中得以保持:一项随访11至13年的随机对照试验。

The positive effect of posterolateral lumbar spinal fusion is preserved at long-term follow-up: a RCT with 11-13 year follow-up.

作者信息

Andersen Thomas, Videbaek Tina S, Hansen Ebbe S, Bünger Cody, Christensen Finn B

机构信息

Orthopaedic Research Laboratory, Department of Orthopaedics E, Aarhus University Hospital, Building 1A, Nørrebrogade 44, 8000, Aarhus C, Denmark.

出版信息

Eur Spine J. 2008 Feb;17(2):272-80. doi: 10.1007/s00586-007-0494-8. Epub 2007 Sep 12.

Abstract

INTRODUCTION

Few studies have investigated the long-term effect of posterolateral lumbar spinal fusion on functional outcome.

AIM

To investigate the long-term result after posterolateral lumbar spinal fusion with and without pedicle screw instrumentation.

METHODS

Questionnaire survey of 129 patients originally randomised to posterolateral lumbar spinal fusion with or without pedicle screw instrumentation. Follow-up included Dallas Pain Questionnaire (DPQ), Oswestry Disability Index (ODI), SF-36 and a question regarding willingness to undergo the procedure again knowing the result as global outcome parameter.

RESULTS

Follow-up was 83% of the original study population (107 patients). Average follow-up time was 12 years (range 11-13 years). DPQ-scores were significantly lower than preoperatively in both groups (P < 0.005) and no drift towards the preoperative level was seen. No difference between the two groups were observed (instrumented vs. non-instrumented): DPQ Daily Activity mean 37.0 versus 32.0, ODI mean 33.4 versus 30.6, SF-36 PCS mean 38.8 versus 39.8, SF-36 MCS mean 49.0 versus 53.3. About 71% in both groups were answered positively to the global outcome question. Patients who had retired due to low back pain had poorer outcome than patients retired for other reasons, best outcome was seen in patients still at work (P = 0.01 or less in all questionnaires, except SF-36 MCS P = 0.08).

DISCUSSION

Improvement in functional outcome is preserved for 10 or more years after posterolateral lumbar spinal fusion. No difference between instrumented fusion and non-instrumented fusion was observed. Patients who have to retired due to low back pain have the smallest improvement.

摘要

引言

很少有研究调查腰椎后外侧融合术对功能结局的长期影响。

目的

研究有无椎弓根螺钉内固定的腰椎后外侧融合术的长期效果。

方法

对129例最初随机分组接受有无椎弓根螺钉内固定的腰椎后外侧融合术的患者进行问卷调查。随访内容包括达拉斯疼痛问卷(DPQ)、奥斯威斯利功能障碍指数(ODI)、SF-36量表以及一个关于知晓结果后是否愿意再次接受该手术的问题作为总体结局参数。

结果

随访率为原研究人群的83%(107例患者)。平均随访时间为12年(范围11 - 13年)。两组患者的DPQ评分均显著低于术前(P < 0.005),且未观察到向术前水平的偏移。两组之间未观察到差异(内固定组与非内固定组):DPQ日常活动评分均值分别为37.0和32.0,ODI均值分别为33.4和30.6,SF-36量表生理健康综合评分(PCS)均值分别为38.8和39.8,SF-36量表心理健康综合评分(MCS)均值分别为49.0和53.3。两组中约71%的患者对总体结局问题给予肯定回答。因腰痛退休的患者结局比因其他原因退休的患者差,仍在工作的患者结局最佳(除SF-36量表MCS评分P = 0.08外,所有问卷中的P值均为0.01或更低)。

讨论

腰椎后外侧融合术后功能结局的改善可持续10年或更长时间。未观察到内固定融合与非内固定融合之间存在差异。因腰痛而不得不退休的患者改善最小。

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