Hedelin Hans, Jonsson Karin
Research and Development Centre and the Department of Urology, Kärnsjukhuset, Skövde, Sweden.
Scand J Urol Nephrol. 2007;41(6):516-20. doi: 10.1080/00365590701428517.
To evaluate how age and the duration of the condition influence the distress caused by the chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to study how heat and cold influence the symptoms associated with CP/ CPPS as reported by patients afflicted with the condition.
Forty-eight men (median age 50 years; age range 27-70 years) who had suffered from CP/CPPS for a duration ranging from 18 months to 40 years were included in the study. The evaluation included determination of the serum prostate-specific antigen level, the National Institutes of Health's Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS).
The mean NIH-CPSI score was 23.0 +/- 4.8. The mean IPSS was 14.3 +/- 7.2. Dysuria was reported by 30 men (63%) and ejaculatory pain by 22 (48%). Men with dysuria had painful ejaculations more often (60%) than men without (22%) (p <0.01). There was a strong negative correlation between age and the NIH-CPSI quality of life (QOL) score (correlation coefficient 0.646; p < 0.001). Independent of age, the duration of the disease also correlated with the NIH-CPSI QOL score (correlation coefficient -0.48; p < 0.02). The total NIH-CPSI score did not correlate with either age or the duration of the disease. Nearly every other man stated that the disease had started in association with a specific event, which for 15 men (31%) included exposure to cold. Forty men (83%) reported that cold caused symptom aggravation and/or induced a relapse. Thirty men (63%) stated that taking a hot bath and 22 (46%) reported that spending time in a hot climate decreased the symptoms.
Age, as well as the duration of the condition, influenced the distress induced by CP/CPPS, suggesting an improved coping ability with time as well as age. The ambient temperature appears to play a role as cold was frequently reported as causing symptom aggravation and heat was often reported to be ameliorating. The mechanisms behind this association between CP/CPPS and temperature as well as the correlation between ejaculatory pain and dysuria require further study.
评估年龄和病情持续时间如何影响慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）所引起的痛苦，并研究热疗和冷疗对患有该疾病的患者报告的与CP/CPPS相关症状的影响。
本研究纳入了48名患有CP/CPPS的男性（年龄中位数为50岁；年龄范围27 - 70岁），其患病持续时间为18个月至40年。评估内容包括血清前列腺特异性抗原水平的测定、美国国立卫生研究院慢性前列腺炎症状指数（NIH - CPSI）和国际前列腺症状评分（IPSS）。
NIH - CPSI平均得分为23.0±4.8。IPSS平均得分为14.3±7.2。30名男性（63%）报告有排尿困难，22名（48%）报告有射精疼痛。有排尿困难的男性射精疼痛的发生率（60%）高于无排尿困难的男性（22%）（p<0.01）。年龄与NIH - CPSI生活质量（QOL）评分之间存在强烈的负相关（相关系数0.646；p<0.001）。与年龄无关，疾病持续时间也与NIH - CPSI QOL评分相关（相关系数 - 0.48；p<0.02）。NIH - CPSI总分与年龄或疾病持续时间均无相关性。几乎每一位男性都表示疾病始于特定事件，其中15名男性（31%）的事件包括暴露于寒冷环境。40名男性（83%）报告寒冷会导致症状加重和/或引发复发。30名男性（63%）表示洗热水澡后症状减轻，22名（46%）报告在炎热气候下症状减轻。
年龄以及病情持续时间会影响CP/CPPS所引起的痛苦，这表明随着时间推移和年龄增长应对能力有所提高。环境温度似乎起到了一定作用，因为经常有报告称寒冷会导致症状加重，而热疗则常常能缓解症状。CP/CPPS与温度之间这种关联背后的机制以及射精疼痛与排尿困难之间的相关性需要进一步研究。
