Giltay Erik J, Kho King H, Blansjaar Ben A
GGZ Delfland, Institute of Mental Health, Delft, The Netherlands.
World J Biol Psychiatry. 2008;9(3):231-5. doi: 10.1080/15622970701310989.
The effects of electroconvulsive therapy (ECT) on serum levels of the acute-phase reactant C-reactive protein (CRP) and intracellular enzymes such as alkaline phosphatase (ALP), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK), have received little attention. If brain cells are damaged, CK-BB, LDH and AST levels are expected to show (minor) elevations. We measured serum levels of prolactin, AST, ALT, LDH, ALP, CK and CRP before and 5 min, 30 min, 4 h, 1 day, 2 days, and 3 days after ECT in 15 consecutive patients (eight women and seven men; mean 53.9 years old, range 3082) who did not receive ECT in the preceding 2 weeks. Prolactin levels increased (P = 0.001), but none of the other mean concentrations significantly increased over time. All concentrations remained within the normal range in every patient, except for five samples with elevated CK levels (range 333-675 IU/l). CK-MB and CK-BB fractions, however, remained low, indicating that skeletal muscle was the source of the CK elevation. Serum levels of markers of brain cell leakage and inflammation remained low following one ECT session, suggesting that ECT does not cause direct brain cell leakage, nor an inflammatory response.
电休克疗法（ECT）对急性期反应物C反应蛋白（CRP）以及细胞内酶如碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和肌酸激酶（CK）血清水平的影响，鲜受关注。如果脑细胞受损，预计CK-BB、LDH和AST水平会出现（轻微）升高。我们对15例连续患者（8名女性和7名男性；平均年龄53.9岁，范围30 - 82岁）在ECT治疗前以及治疗后5分钟、30分钟、4小时、1天、2天和3天测量了催乳素、AST、ALT、LDH、ALP、CK和CRP的血清水平，这些患者在之前2周内未接受过ECT治疗。催乳素水平升高（P = 0.001），但其他平均浓度均未随时间显著升高。除了5个CK水平升高的样本（范围333 - 675 IU/l）外，所有患者的所有浓度均保持在正常范围内。然而，CK-MB和CK-BB组分仍较低，表明骨骼肌是CK升高的来源。一次ECT治疗后，脑细胞渗漏和炎症标志物的血清水平仍较低，这表明ECT不会导致直接的脑细胞渗漏，也不会引发炎症反应。
