Naoe S, Takahashi K, Masuda H, Tanaka N
Department of Pathology, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
Acta Pathol Jpn. 1991 Nov;41(11):785-97. doi: 10.1111/j.1440-1827.1991.tb01620.x.
Kawasaki disease (KD, or acute febrile mucocutaneous lymph node syndrome (MCLS)) was first described as a clinical entity in 1967 by Dr. Tomisaku Kawasaki of the Japan Red Cross Medical Center. Originally, it was thought to have a favorable prognosis, but as epidemiological surveys, augmented by pathological studies, have shown, it has come to be recognized as an often fatal disorder. In this report, the clinical symptoms, historical background, present status of research and epidemiological problems of KD are first described, and then we present a pathological and morphological outline of KD, focusing on pathological changes in the blood vessels, and the relationships of these changes to 1) the morphogenesis of arteritis, 2) the mechanism of coronary artery aneurysm formation and its sequelae, and 3) juvenile arteriosclerosis.
川崎病（KD，或急性发热性皮肤黏膜淋巴结综合征（MCLS））于1967年由日本红十字会医疗中心的川崎富作医生首次作为一种临床实体进行描述。最初，人们认为它预后良好，但正如流行病学调查以及病理学研究表明的那样，它已被公认为一种往往致命的疾病。在本报告中，首先描述了川崎病的临床症状、历史背景、研究现状和流行病学问题，然后我们呈现川崎病的病理和形态学概述，重点关注血管的病理变化，以及这些变化与1）动脉炎的形态发生、2）冠状动脉瘤形成及其后遗症的机制、3）青少年动脉硬化之间的关系。
