Ramasamy Ravichandran, Yan Shi Fang, Schmidt Ann Marie
Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Mol Nutr Food Res. 2007 Sep;51(9):1111-5. doi: 10.1002/mnfr.200700008.
Advanced glycation endproducts (AGEs) are an heterogenous class of compounds formed by diverse stimuli, including hyperglycemia, oxidative stress, inflammation, renal failure, and innate aging. Recent evidence suggests that dietary sources of AGE may contribute to pathology. AGEs impart diverse effects in cells; evidence strongly suggests that crosslinking of proteins by AGEs may irrevocably alter basement membrane integrity and function. In addition, the ability of AGEs to bind to cells and activate signal transduction, thereby affecting broad properties in the cellular milieu, indicates that AGEs are not innocent bystanders in the diseases of AGEing. Here, we present evidence that receptor for AGE (RAGE) is a receptor for AGEs.
晚期糖基化终末产物（AGEs）是一类由多种刺激因素形成的异质性化合物，这些刺激因素包括高血糖、氧化应激、炎症、肾衰竭和自然衰老。最近的证据表明，膳食中的AGEs可能与病理过程有关。AGEs在细胞中具有多种作用；有力的证据表明，AGEs使蛋白质交联可能会不可逆转地改变基底膜的完整性和功能。此外，AGEs与细胞结合并激活信号转导的能力，从而影响细胞环境中的广泛特性，这表明AGEs在衰老相关疾病中并非无辜的旁观者。在此，我们提供证据表明，晚期糖基化终末产物受体（RAGE）是AGEs的一种受体。
