Greshock Thomas J, Williams Robert M
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, USA.
Org Lett. 2007 Oct 11;9(21):4255-8. doi: 10.1021/ol701845t. Epub 2007 Sep 14.
The direct conversion of beta-hydroxyproline derivatives into 5-hydroxypyrazin-2(1H)-ones under Mitsunobu conditions has been discovered to be a general biomimetic protocol generating IMDA intermediates and has been applied to the concise, biomimetic total syntheses of D,L-stephacidin A and D,L-brevianamide B.
已发现，在光延反应条件下将β-羟基脯氨酸衍生物直接转化为5-羟基吡嗪-2(1H)-酮是一种生成IMDA中间体的通用仿生方法，并已应用于D,L-司替巴丁A和D,L-短杆菌酰胺B的简洁仿生全合成。
