Wright Alison J, Aveyard Paul, Guo Boliang, Murphy Michael, Brown Karen, Marteau Theresa M
Health Psychology, King's College London, London, UK.
Addiction. 2007 Oct;102(10):1657-64. doi: 10.1111/j.1360-0443.2007.01937.x.
Pharmacogenetic smoking cessation interventions would involve smokers being given information about the influence of genes on their behaviour. However, attributing smoking to genetic causes may reduce perceived control over smoking, reducing quit attempt success. This study examines whether attributing smoking to genetic influences is associated with reduced quitting and whether this effect is mediated by perceived control over smoking.
Cohort study.
A total of 792 smokers, participating in a trial of nicotine replacement therapy (NRT)-assisted smoking cessation. Participants were informed that the trial investigated relationships between genetic markers and smoking behaviour, but personalized genetic feedback was not provided.
Primary care in Oxfordshire and Buckinghamshire, UK.
Perceived control over smoking and perceived importance of genetic factors in causing smoking assessed pre-quit; abstinence 4, 12, 26 and 52 weeks after the start of treatment.
A total of 515 smokers (65.0%) viewed genetic factors as playing some role in causing their smoking. They had lower perceived control over smoking than smokers who viewed genetic factors as having no role in causing their smoking. Attributing smoking to genetic causes was not associated significantly with a lower probability of quit attempt success.
Attributing smoking to genetic factors was associated with lower levels of perceived control over smoking but not lower quit rates. This suggests that learning of one's genetic predisposition to smoking during a pharmacogenetically tailored smoking cessation intervention may not deter quitting. Further research should examine whether the lack of impact of genetic attributions on quit attempt success is also found in smokers provided with personalized genetic feedback.
药物遗传学戒烟干预措施包括向吸烟者提供有关基因对其行为影响的信息。然而，将吸烟归因于遗传原因可能会降低对吸烟的感知控制，从而降低戒烟尝试的成功率。本研究旨在探讨将吸烟归因于遗传影响是否与戒烟率降低有关，以及这种影响是否通过对吸烟的感知控制来介导。
队列研究。
共有792名吸烟者参与了一项尼古丁替代疗法（NRT）辅助戒烟试验。参与者被告知该试验研究基因标记与吸烟行为之间的关系，但未提供个性化的基因反馈。
英国牛津郡和白金汉郡的初级医疗保健机构。
在戒烟前评估对吸烟的感知控制以及遗传因素在导致吸烟方面的感知重要性；在治疗开始后4周、12周、26周和52周评估戒烟情况。
共有515名吸烟者（65.0%）认为遗传因素在导致其吸烟方面起到了一定作用。他们对吸烟的感知控制低于那些认为遗传因素在导致其吸烟方面没有作用的吸烟者。将吸烟归因于遗传原因与戒烟尝试成功的可能性较低并无显著关联。
将吸烟归因于遗传因素与对吸烟的较低感知控制水平相关，但与较低的戒烟率无关。这表明在药物遗传学定制的戒烟干预过程中了解自己的吸烟遗传易感性可能不会阻碍戒烟。进一步的研究应探讨在提供个性化基因反馈的吸烟者中是否也发现遗传归因对戒烟尝试成功缺乏影响。
