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芫花素对急性炎症的体内作用。

In vivo effect of casticin on acute inflammation.

作者信息

Lin Shan, Zhang Hong, Han Ting, Wu Jin-Zhong, Rahman Khalid, Qin Lu-Ping

机构信息

Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province 350003, China.

出版信息

Zhong Xi Yi Jie He Xue Bao. 2007 Sep;5(5):573-6. doi: 10.3736/jcim20070520.

DOI:10.3736/jcim20070520
PMID:17854563
Abstract

OBJECTIVE

To investigate the anti-inflammatory effect of casticin of Fructus Viticis.

METHODS

Observations were made on the anti-inflammatory effect of casticin in the models of acute inflammation in vivo.

RESULTS

Casticin inhibited significantly xylene-induced mouse ear edema, egg albumen-induced rat paw edema and acetic acid-induced mouse vascular permeability.

CONCLUSION

Casticin has significant anti-inflammatory effect on acute inflammation, which is probably related to the inhibition of the inflammation factors. Casticin is the effective constituent contributing to the anti-inflammatory effect of Fructus Viticis.

摘要

目的

研究蔓荆子中紫花牡荆素的抗炎作用。

方法

观察紫花牡荆素在体内急性炎症模型中的抗炎作用。

结果

紫花牡荆素能显著抑制二甲苯所致小鼠耳肿胀、蛋清所致大鼠足肿胀及醋酸所致小鼠血管通透性增加。

结论

紫花牡荆素对急性炎症有显著抗炎作用，可能与抑制炎症因子有关。紫花牡荆素是蔓荆子抗炎作用的有效成分。

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