Rudich Assaf, Kanety Hannah, Bashan Nava
Department of Clinical Biochemistry Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84103 Israel.
Trends Endocrinol Metab. 2007 Oct;18(8):291-9. doi: 10.1016/j.tem.2007.08.006. Epub 2007 Sep 12.
Obesity has been proposed to inflict a variety of stresses on adipose tissue, including inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which probably contribute to the co-morbidities associated with obesity. Here, we review the evidence supporting the development of various obesity-related stresses and the activation of several stress-sensing pathways, specifically in adipocytes and/or adipose tissue, which manifest metabolic and endocrine dysfunction frequently in obesity. As the central role of adipose tissue in regulating whole-body metabolism is elucidated, understanding adipose tissue stress-sensing pathways might provide potential new therapeutic targets to attenuate obesity-related morbidity.
肥胖被认为会给脂肪组织带来多种应激，包括炎症应激、代谢应激、氧化应激和内质网应激。通过激活“应激感应通路”，会产生代谢和内分泌改变，这可能会导致与肥胖相关的合并症。在此，我们综述了支持各种与肥胖相关应激的发展以及几种应激感应通路激活的证据，特别是在脂肪细胞和/或脂肪组织中，这些应激感应通路在肥胖中经常表现出代谢和内分泌功能障碍。随着脂肪组织在调节全身代谢中的核心作用得到阐明，了解脂肪组织应激感应通路可能会为减轻肥胖相关发病率提供潜在的新治疗靶点。
