Vernaeve Valérie, Bodri Daniel, Colodrón Marta, Vidal Ricard, Durbán Mercé, Coll Oriol
Clinica Eugin, Calle Entenza 293-295, 08029, Barcelona, Spain.
Hum Reprod. 2007 Nov;22(11):2863-7. doi: 10.1093/humrep/dem276. Epub 2007 Sep 12.
Information is scarce regarding the outcome of oocyte donation (OD) in patients with a history of cancer treatment. Therefore, we conducted a matched controlled analysis on the outcome of OD in these recipients.
Between January 2000 and November 2005, 33 patients with a history of chemotherapy and/or radiotherapy had an OD cycle. Matching was performed to the chronologically closest patient without a history of cancer therapy by number of days of hormonal stimulation before embryo replacement, number of replaced embryos, day of embryo transfer and origin of sperm.
The primary diseases of the patients were Hodgkin's lymphoma (n = 12), non-Hodgkin's lymphoma (n = 3), leukaemia (n = 7), ovarian cancer (n = 6), Ewing's sarcoma (n = 2), breast cancer (n = 1), sympathoblastoma (n = 1) and histiocytosis X (n = 1). Twenty-three patients had undergone chemotherapy and radiotherapy, nine patients chemotherapy only and one radiotherapy only. The mean age of the recipients was 33.1 years [95% confidence interval (CI) 30.9-35.3] and 39.6 (95% CI 37.1-42.1) in the study and control groups, respectively. The average number of received oocytes and transferred embryos, was similar in both groups. Nineteen (57.6%) versus 13 (39.4%) pregnancies resulting in an ongoing pregnancy (i.e. viable at 12 weeks) in 15 (45.4%) versus 9 cycles (27.3%) (NS) were obtained in study and control groups, respectively. Implantation rate in study and control groups was 35.8 versus 17.9%, respectively (P = 0.02).
The results suggest that patients with a history of cancer treatment have a pregnancy rate after OD similar to that in the general population of oocyte recipients.
关于有癌症治疗史患者的卵母细胞捐赠（OD）结局的信息很少。因此，我们对这些受者的OD结局进行了匹配对照分析。
在2000年1月至2005年11月期间，33例有化疗和/或放疗史的患者进行了OD周期。通过胚胎移植前激素刺激天数、移植胚胎数、胚胎移植日和精子来源，与没有癌症治疗史的按时间顺序最接近的患者进行匹配。
患者的主要疾病为霍奇金淋巴瘤（n = 12）、非霍奇金淋巴瘤（n = 3）、白血病（n = 7）、卵巢癌（n = 6）、尤因肉瘤（n = 2）、乳腺癌（n = 1）、成神经细胞瘤（n = 1）和组织细胞增多症X（n = 1）。23例患者接受了化疗和放疗，9例仅接受化疗，1例仅接受放疗。研究组和对照组受者的平均年龄分别为33.1岁[95%置信区间（CI）30.9 - 35.3]和39.6岁（95% CI 37.1 - 42.1）。两组接受的卵母细胞和移植胚胎的平均数量相似。研究组和对照组分别有19例（57.6%）和13例（39.4%）妊娠，其中15个周期（45.4%）和9个周期（27.3%）获得持续妊娠（即12周时存活）（无显著性差异）。研究组和对照组的着床率分别为35.8%和17.9%（P = 0.02）。
结果表明，有癌症治疗史的患者在OD后的妊娠率与卵母细胞受者的一般人群相似。
