Dunnington E A, Siegel P B, Gross W B
Poultry Science Department, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Avian Dis. 1991 Oct-Dec;35(4):937-40.
Relative sensitivity to Escherichia coli challenge was evaluated in white leg-horn chickens that had been selected for high antibody (HA) or low antibody (LA) response and that differed in haplotypes at the major histocompatibility complex (MHC). Assessments were made of relative body-weight change and of heart and air-sac lesions after inoculation of 10(6), 10(5), or 10(4) E. coli via the posterior thoracic air sac. As has previously been reported, chicks from line HA were more sensitive to E. coli than those from line LA. Lesion scores were 1.58 +/- 0.12 in line HA and 1.02 +/- 0.12 in line LA (mean +/- S.E.), and ranged from 0.99 +/- 0.14 with the lowest dose of E. coli to 1.79 +/- 0.15 for the highest dose. Relative body-weight change to 72 hours after inoculation was greater in line LA (7.5 +/- 0.5) than in line HA (4.4 +/- 0.8). There was no apparent resistance or susceptibility conferred to chickens in either the HA or LA genetic background as a result of haplotypes present at the MHC.
在经过高抗体（HA）或低抗体（LA）反应选育且主要组织相容性复合体（MHC）单倍型不同的白来航鸡中，评估了对大肠杆菌攻击的相对敏感性。通过后胸气囊接种10⁶、10⁵或10⁴个大肠杆菌后，对相对体重变化以及心脏和气囊损伤进行了评估。如先前报道，HA系雏鸡比LA系雏鸡对大肠杆菌更敏感。HA系的损伤评分为1.58±0.12，LA系为1.02±0.12（平均值±标准误），范围从最低剂量大肠杆菌时的0.99±0.14到最高剂量时的1.79±0.15。接种后72小时，LA系（7.5±0.5）的相对体重变化大于HA系（4.4±0.8）。由于MHC存在的单倍型，HA或LA遗传背景的鸡均未表现出明显的抗性或易感性。
