Ensoli F, Fiorelli V, Mezzaroma I, D'Offizi G, Rainaldi L, Luzi G, Fiorilli M, Aiuti F
Department of Allergy and Clinical Immunology, University of Rome, Italy.
AIDS. 1991 Oct;5(10):1195-9. doi: 10.1097/00002030-199110000-00007.
It has been reported that the period of latency between HIV-1 infection and the production of antibodies against the virus is sometimes prolonged for greater than 6 months. However, the data supporting this are still controversial and it is not known whether these individuals are actually infectious, especially through body fluids. We have performed a prospective study of 65 high-risk HIV-1-antibody-negative individuals who were followed-up for a period of at least 1 year. Twelve of these individuals were shown by polymerase chain reaction (PCR) to be carriers of HIV-1 proviral sequences. The virus was isolated from lymphocytes in five out of 10 PCR-positive subjects and from cell-free plasma in two. Our data indicate that in some cases delayed seroconversions may be associated with productive infection, suggesting that mechanism(s) other than viral latency may be responsible for the absence of antibody responses to HIV-1 proteins.
据报道，HIV-1感染与产生针对该病毒的抗体之间的潜伏期有时会延长至6个月以上。然而，支持这一观点的数据仍存在争议，并且尚不清楚这些个体是否具有传染性，尤其是通过体液传播。我们对65名高危HIV-1抗体阴性个体进行了一项前瞻性研究，对他们进行了至少1年的随访。其中12名个体通过聚合酶链反应（PCR）被证明是HIV-1前病毒序列的携带者。在10名PCR阳性受试者中，有5名从淋巴细胞中分离出病毒，2名从无细胞血浆中分离出病毒。我们的数据表明，在某些情况下，血清转化延迟可能与有病毒复制的感染有关，这表明除了病毒潜伏外，其他机制可能是导致对HIV-1蛋白无抗体反应的原因。
