Timoshin S S, Shvets S I, Radivoz M I, Aleksandrovich A G, Mel'nik E I
Biull Eksp Biol Med. 1991 Aug;112(8):130-2.
Using radiography with H-thymidine method we studied the synthesis of DNA process in pyloric parts of stomach epithelium in white rats, which have been five-fold effected by different kinds of stressors against a background of dalargin injections. In the first hour after animals were stressed, DNA synthesis was depressed. Dalargin injections caused DNA synthesis normalization in the first hour after hypoxia and hyperthermia. Since 24 hours after hyperthermia and immobilization against a background of dalargin injections the normalization of DNA synthesis took place, and after hypoxia the post-stressing IMN activation was growing week. One of the mechanisms of dalargin correction of DNA synthesis breach under the influence of stressors is a stabilization of noradrenaline and histamine concentration in tissue of the stomach.
我们使用放射自显影术结合 H-胸腺嘧啶核苷法，研究了在大白鼠胃幽门部上皮细胞中 DNA 的合成过程。这些大白鼠在注射达乐argin 的背景下，受到了五种不同应激源的影响。在动物受到应激后的第一小时，DNA 合成受到抑制。注射达乐argin 可使缺氧和高温应激后第一小时的 DNA 合成恢复正常。在注射达乐argin 的背景下，高温和固定应激 24 小时后，DNA 合成恢复正常，而缺氧应激后应激后免疫激活反应逐渐减弱。达乐argin 在应激源影响下纠正 DNA 合成障碍的机制之一，是稳定胃组织中去甲肾上腺素和组胺的浓度。
