Idutsu Kensaku, Abe Yasunobu, Otonari Jun, Tachikawa Yoshimichi, Ohtsuka Rie, Choi Ilseung, Muta Koichiro, Takayanagi Ryoichi
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
Rinsho Ketsueki. 2007 Aug;48(8):664-6.
Human herpesvirus 6 (HHV-6) reactivates in immunocompromised patients, and HHV-6 encephalitis has often been reported as a complication of transplantation. We describe a 37-year-old woman with the acute type of adult T-cell leukemia/lymphoma who developed HHV-6 encephalitis before chemotherapy. The patient's main symptoms were disorientation and short-term memory loss. Magnetic resonance imaging of the brain showed a bilateral T2 prolongation within the temporal lobes, and HHV-6 DNA was detected in the cerebrospinal fluid (CSF). After treatment with ganciclovir, HHV-6 DNA disappeared from the CSF and the patient's symptoms gradually improved. HHV-6 encephalitis should be listed as a differential diagnosis of encephalopathy developing in immunocompromised patients.
人类疱疹病毒6型（HHV-6）在免疫功能低下的患者中会重新激活，HHV-6脑炎常被报道为移植后的并发症。我们描述了一名37岁患急性型成人T细胞白血病/淋巴瘤的女性，她在化疗前患上了HHV-6脑炎。患者的主要症状是定向障碍和短期记忆丧失。脑部磁共振成像显示双侧颞叶T2信号延长，脑脊液（CSF）中检测到HHV-6 DNA。使用更昔洛韦治疗后，脑脊液中的HHV-6 DNA消失，患者症状逐渐改善。HHV-6脑炎应列为免疫功能低下患者发生脑病的鉴别诊断之一。
