Mosca Andrea, Goodall Ian, Hoshino Tadao, Jeppsson Jan O, John W Garry, Little Randie R, Miedema Kor, Myers Gary L, Reinauer Hans, Sacks David B, Weykamp Cas W
Centre for Metrological Traceability in Laboratory Medicine (CIRME), Dept. Science and Biomedical Technology, University of Milano, Italy.
Clin Chem Lab Med. 2007;45(8):1077-80. doi: 10.1515/CCLM.2007.246.
The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as betaN1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.
糖化血红蛋白的测定是糖尿病患者血糖控制监测的核心内容。目前市面上至少有30种不同的实验室检测方法可用于测定血液中糖化血红蛋白（HbA1c）的比例。1995年，国际临床化学和检验医学联合会（IFCC）成立了一个工作组（IFCC WG-HbA1c），以实现HbA1c测定的国际标准化。主要成果可总结如下：a）已采用纯化的一级校准品建立了参考测量程序；b）在全球范围内建立了参考实验室网络；c）已开始致力于实现溯源至IFCC参考系统。IFCC WG-HbA1c认可IFCC-IUPAC命名、性质和单位委员会的建议，即IFCC参考测量程序所测定的分析物已被定义为βN1-脱氧果糖基血红蛋白，推荐的测量单位为mmol/mol。IFCC WG-HbA1c建议在临床实践中继续使用HbA1c这一名称。
