Baker Jessica H, Mazzeo Suzanne E, Kendler Kenneth S
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA.
Int J Eat Disord. 2007 Dec;40(8):673-8. doi: 10.1002/eat.20472.
Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD.
Participants included 490 monozygotic and 354 dizygotic female twins and 930 females from opposite sex pairs. Multiple logistic regression analyses were used to test shared correlates and mediators. Bivariate twin analyses were used to investigate the contribution of genes and environment to the correlation between BN and DUD.
Depression, neuroticism, and childhood sexual abuse (CSA) mediated the association between BN and DUD regardless of which disorder was used as the dependent variable. Analyses also indicated genetic and nonshared environmental overlap between BN and DUD.
The association between BN and DUD is due mostly to overlapping genetic influences with a smaller contribution from nonshared environment. Depression, neuroticism, and CSA are likely important shared correlates.
先前的研究表明神经性贪食症（BN）与药物使用障碍（DUD）之间存在关联。本研究的目的是调查对BN和DUD共病的可能影响。
参与者包括490对同卵和354对异卵双胞胎女性以及930对异性配对的女性。采用多重逻辑回归分析来检验共同的相关因素和中介因素。双变量双胞胎分析用于研究基因和环境对BN与DUD之间相关性的贡献。
无论将哪种障碍用作因变量，抑郁、神经质和童年期性虐待（CSA）都介导了BN与DUD之间的关联。分析还表明BN与DUD之间存在遗传和非共享环境重叠。
BN与DUD之间的关联主要归因于重叠的遗传影响，非共享环境的贡献较小。抑郁、神经质和CSA可能是重要的共同相关因素。
