Sheikh Javed, Weller Peter F
Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, DA-617, Boston, MA 02215, USA.
Immunol Allergy Clin North Am. 2007 Aug;27(3):333-55. doi: 10.1016/j.iac.2007.07.007.
Hypereosinophilic syndrome (HES) or syndromes are disorders characterized by chronic peripheral blood hypereosinophilia with damage to various organs due toeosinophilic infiltration and release of mediators. HES is most accurately described as a collection of heterogeneous disorders, with some similarities in clinical features, but many differences. Based on recent advances in molecular and genetic diagnostic techniques and increasing experience with differences in clinical features and prognosis, some subtypes of HES have been defined, such as myeloproliferative variants, including chronic eosinophilic leukemia, and lymphocytic variants, but other subtypes remain undefined. Recent evidence suggests that, in addition to differences in clinical features, the range of complications, treatment options, and prognoses differs significantly among the myeloproliferative, lymphocytic, and undefined variants of HES.
高嗜酸性粒细胞综合征（HES）或相关综合征是一类以慢性外周血嗜酸性粒细胞增多为特征的疾病，由于嗜酸性粒细胞浸润和介质释放而导致各器官受损。HES最准确地描述为一组异质性疾病，临床特征有一些相似之处，但也有许多不同之处。基于分子和基因诊断技术的最新进展以及对临床特征和预后差异的更多经验，已定义了一些HES亚型，如骨髓增殖性变异型，包括慢性嗜酸性粒细胞白血病，以及淋巴细胞变异型，但其他亚型仍未明确。最近的证据表明，除了临床特征不同外，HES的骨髓增殖性、淋巴细胞性和未明确的变异型在并发症范围、治疗选择和预后方面也有显著差异。
