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一名接受口服避孕药治疗的青少年出现仅限于口腔黏膜的多形红斑。

Erythema multiforme limited to the oral mucosa in a teenager on oral contraceptive therapy.

作者信息

Jawetz Robert E, Elkin Avigayil, Michael Lisa, Jawetz Sheryl A, Shin Helen T

机构信息

Tenafly Pediatrics, Tenafly, New Jersey, USA.

出版信息

J Pediatr Adolesc Gynecol. 2007 Oct;20(5):309-13. doi: 10.1016/j.jpag.2007.02.001.

DOI:10.1016/j.jpag.2007.02.001
PMID:17868899
Abstract

BACKGROUND

Erythema multiforme has been linked to numerous drugs and infectious agents. A link to oral contraceptive use has been reported in the past in the adult population but thus far has not been reported in children or adolescents.

CASE

We report the case of an 18-yr-old female who developed oral erosions consistent with erythema multiforme two and a half weeks after initiating therapy with an oral contraceptive agent. A thorough examination for other inciting factors was negative, and the lesions slowly resolved over the course of 3 weeks.

CONCLUSIONS

This case illustrates that erythema multiforme should be considered in the differential diagnosis of adolescents with oral erosions who have been prescribed oral contraceptives.

摘要

背景

多形红斑与多种药物和感染因子有关。过去曾报道成人使用口服避孕药与之有关,但迄今为止儿童或青少年中尚未有报道。

病例

我们报告一例18岁女性病例,该患者在开始使用口服避孕药治疗两周半后出现了符合多形红斑的口腔糜烂。对其他诱发因素进行的全面检查结果为阴性,病变在3周内逐渐消退。

结论

该病例表明,对于服用口服避孕药的口腔糜烂青少年患者,鉴别诊断时应考虑多形红斑。

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Erythema multiforme limited to the oral mucosa in a teenager on oral contraceptive therapy.一名接受口服避孕药治疗的青少年出现仅限于口腔黏膜的多形红斑。
J Pediatr Adolesc Gynecol. 2007 Oct;20(5):309-13. doi: 10.1016/j.jpag.2007.02.001.
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Erythema multiforme.多形红斑
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Drug-induced oral erythema multiforme. Results of a long-term retrospective study.药物性口腔多形红斑。一项长期回顾性研究的结果。
Dermatologica. 1984;168(1):35-40.
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[Individualization of low-dose oral contraceptives. Pharmacological principles and practical indications for oral contraceptives].[低剂量口服避孕药的个体化。口服避孕药的药理学原理及实际应用指征]
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Risk of hyperkalemia in women taking ethinylestradiol/drospirenone and other oral contraceptives.服用炔雌醇/屈螺酮及其他口服避孕药的女性发生高钾血症的风险。
Contraception. 2008 Nov;78(5):377-83. doi: 10.1016/j.contraception.2008.06.012. Epub 2008 Aug 8.
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[Oral effects of systemic medication in elderly].[全身性药物对老年人的口腔影响]
Rev Med Chir Soc Med Nat Iasi. 2009 Jul-Sep;113(3):885-91.
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A combined oral contraceptive containing drospirenone changes neither endothelial function nor hemodynamic parameters in healthy young women: a prospective clinical trial.一种含有屈螺酮的复方口服避孕药不会改变健康年轻女性的内皮功能或血液动力学参数:一项前瞻性临床试验。
Contraception. 2012 Jul;86(1):35-41. doi: 10.1016/j.contraception.2011.08.017. Epub 2012 Mar 31.
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[Adverse effects of drugs on the oral mucosa--incidence and clinical picture in clinical patients].[药物对口腔黏膜的不良反应——临床患者中的发生率及临床表现]
Z Hautkr. 1982 Oct 1;57(19):1389-96.
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Risk of thromboembolism in women taking ethinylestradiol/drospirenone and other oral contraceptives.服用炔雌醇/屈螺酮及其他口服避孕药的女性发生血栓栓塞的风险
Obstet Gynecol. 2007 Sep;110(3):587-93. doi: 10.1097/01.AOG.0000279448.62221.a8.

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An unusual presentation of erythema multiforme in a paediatric patient.一名儿科患者多形红斑的不寻常表现。
Eur Arch Paediatr Dent. 2015 Jun;16(3):297-302. doi: 10.1007/s40368-015-0181-0. Epub 2015 Apr 8.
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