治疗类风湿性关节炎的新药在孕期服用安全吗？致畸学信息专家组织（OTIS）的研究。
Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.
作者信息
Chambers Christina, Koren Gideon, Tutuncu Zuhre N, Johnson Diana, Jones Kenneth L
出版信息
Can Fam Physician. 2007 Mar;53(3):409-12.
QUESTION
I have a patient planning pregnancy who has resistant rheumatoid arthritis that will require treatment with some of the "new" medications. Which ones are safe to use during pregnancy, and which ones do we know enough about to tell whether they are safe or not?
ANSWER
For most new disease-modifying biologic medications, we have few data on safety. More and more reassuring data are accumulating on azathioprine and cyclosporine. When you treat this patient, you can help in gathering such data by contacting the Organization of Teratology Information Specialists' Autoimmune Disease in Pregnancy study through Motherisk at 877 311-8972.
问题
我有一位计划怀孕的患者，患有难治性类风湿关节炎，需要使用一些“新型”药物进行治疗。哪些药物在孕期使用是安全的，哪些药物我们掌握了足够信息来判断其是否安全？
答案
对于大多数新型改善病情的生物药物，我们几乎没有关于其安全性的数据。关于硫唑嘌呤和环孢素，越来越多令人安心的数据正在积累。在治疗这位患者时，你可以通过拨打877 311 - 8972联系母胎医学中心的致畸信息专家组织的孕期自身免疫疾病研究，协助收集此类数据。
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