羟氯喹与狼疮妊娠：36例病例系列回顾
Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases.
作者信息
Buchanan N M, Toubi E, Khamashta M A, Lima F, Kerslake S, Hughes G R
机构信息
Lupus Pregnancy Clinic, St Thomas' Hospital, London, United Kingdom.
出版信息
Ann Rheum Dis. 1996 Jul;55(7):486-8. doi: 10.1136/ard.55.7.486.
Abstract
OBJECTIVE
To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ).
METHODS
The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome.
RESULTS
HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar.
CONCLUSION
HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.
摘要
目的
研究暴露于羟氯喹（HCQ）的狼疮患者的母婴妊娠结局。
方法
回顾了一家狼疮妊娠中心33名在孕期（共36次妊娠）暴露于HCQ的女性以及53名对照患者的病历，以确定狼疮活动情况、产科经历和婴儿结局。
结果
HCQ显然无致畸性。两组的狼疮活动情况和产科结局相似。
结论
狼疮患者孕期继续使用HCQ可能是安全的，但开始治疗并无明显益处。
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