Nielsen O H, Andreasson B, Bondesen S, Jarnum S
Scand J Gastroenterol. 1983 Sep;18(6):735-42. doi: 10.3109/00365528309182088.
The course of pregnancy in 97 women with ulcerative colitis was studied over a 12-year period. During this period they had 173 pregnancies and delivered 136 children. There were two gemellary deliveries. Nine women had a spontaneous and 16 an induced abortion, of which 4 were performed on therapeutic indication. For a woman with ulcerative colitis the risk of an exacerbation of the bowel disease was 32% per year in her fertile years, whereas it was 34% per year during pregnancy. This difference is not statistically significant. As compared with women with an inactive bowel disease, women in whom the disease was active at the start of pregnancy had a small but significantly greater risk of spontaneous abortion and premature delivery. The frequency of malformations, prematurity, and neonatal hyperbilirubinaemia was not higher in the children of ulcerative colitis mothers than in those of healthy mothers. Treatment with sulphasalazine, salazosulphadimidine, and corticosteroids had no influence on the course and outcome of pregnancy. Birth length and weight of the children of mothers with ulcerative colitis equalled those for children of healthy mothers. In conclusion, pregnancy does not necessitate any change in the usual medical treatment of ulcerative colitis. Women with ulcerative colitis should be advised preferably to conceive at a time when their bowel disease is inactive. Generally, ulcerative colitis constitutes no indication for induced abortion.
在12年的时间里，对97例溃疡性结肠炎女性患者的妊娠过程进行了研究。在此期间，她们共怀孕173次，分娩136名婴儿。有2例双胎分娩。9名女性自然流产，16名女性人工流产，其中4例是出于治疗需要。对于患有溃疡性结肠炎的女性，在其育龄期肠道疾病加重的风险为每年32%，而在孕期则为每年34%。这种差异无统计学意义。与肠道疾病不活动的女性相比，妊娠开始时疾病活动的女性自然流产和早产的风险虽小但显著更高。溃疡性结肠炎母亲所生子女的畸形、早产和新生儿高胆红素血症的发生率并不高于健康母亲所生子女。柳氮磺胺吡啶、水杨酸偶氮磺胺嘧啶和皮质类固醇治疗对妊娠过程和结局没有影响。溃疡性结肠炎母亲所生子女的出生身长和体重与健康母亲所生子女相当。总之，妊娠并不需要对溃疡性结肠炎的常规治疗做出任何改变。最好建议患有溃疡性结肠炎的女性在肠道疾病不活动时受孕。一般来说，溃疡性结肠炎不是人工流产的指征。
