微小RNA在基因调控中的靶向特异性效应器和全局效应器
Target-specific and global effectors in gene regulation by MicroRNA.
作者信息
Levine Erel, Ben Jacob Eshel, Levine Herbert
机构信息
Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California, USA.
出版信息
Biophys J. 2007 Dec 1;93(11):L52-4. doi: 10.1529/biophysj.107.118448. Epub 2007 Sep 14.
MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular pathways and intercellular coordination, for example during embryonic development. Yet, the basic mechanism by which this silencing is accomplished is still not understood. For example, it is not known to what extent and through what process does the suppression of protein accumulation accompany a reduction in mRNA level. Here we present a simple quantitative modeling approach to microRNA mediated silencing. We show how differential responses of the mRNA- and protein levels may be tuned by target-specific parameters and how global effectors may alter this behavior for some-but not all-miRNA targets in the cell.
微小RNA负责转录后基因沉默，这是关键细胞通路和细胞间协调的一部分，例如在胚胎发育过程中。然而，这种沉默实现的基本机制仍不清楚。例如，尚不清楚蛋白质积累的抑制在多大程度上以及通过什么过程伴随着mRNA水平的降低。在这里，我们提出了一种简单的定量建模方法来研究微小RNA介导的沉默。我们展示了mRNA和蛋白质水平的差异反应如何通过靶标特异性参数进行调节，以及全局效应器如何改变细胞中某些（但不是所有）微小RNA靶标的这种行为。
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