Thomas Wayne R, Hales Belinda J
Centre for Child Health Research University of Western Australia, Telethon Institute for Child, Health Research, 100 Roberts Road, Subiaco, Western Australia, 6008, Australia.
Immunol Res. 2007;37(3):187-99. doi: 10.1007/BF02697369.
House dust mites provide well-characterized proteins to study human responses to inhaled antigens. Even in the absence of allergy they induce a high frequency of T cell precursors. The healthy response manifests by T cell proliferation and Th1 cytokines with little antibody. Responses of allergic people include Th1 and Th2 cytokines and IgE, IgG1, and IgG4 antibodies. Regulatory cells limit effector responses in healthy people. About half the IgE and IgG antibodies bind the group 1 and 2 allergens and 30% bind the group 4, 5, and 7 allergens. Although HLA independent, the recognition of the group 1 allergen shows an immunodominant region and a T cell receptor bias. The major allergens are not produced in higher amounts than many of the poorly non-allergenic proteins. The non-allergenic mite ferritin antigen shows high T cell proliferative responses with mixed cytokine production.
屋尘螨提供了特征明确的蛋白质，用于研究人类对吸入性抗原的反应。即使在没有过敏的情况下，它们也会诱导高频的T细胞前体。健康人的反应表现为T细胞增殖和少量抗体的Th1细胞因子。过敏人群的反应包括Th1和Th2细胞因子以及IgE、IgG1和IgG4抗体。调节性细胞限制健康人的效应反应。大约一半的IgE和IgG抗体结合1组和2组变应原，30%结合4组、5组和7组变应原。虽然与HLA无关，但对1组变应原的识别显示出一个免疫显性区域和T细胞受体偏好。主要变应原的产生量并不比许多低变应原性蛋白质高。非变应原性螨铁蛋白抗原显示出高T细胞增殖反应，并伴有混合细胞因子产生。
