Ye Hui, Cotic Marija, Carlen Peter L
Toronto Western Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada.
J Neural Eng. 2007 Sep;4(3):283-93. doi: 10.1088/1741-2560/4/3/014. Epub 2007 Jul 3.
Time-varying magnetic fields can induce electric fields in the neuronal tissue, a phenomenon that has been recently explored in clinical applications such as peripheral nerve stimulation and transcranial magnetic stimulation. Although the transmembrane potential induced during direct electric stimulation has already been the subject of a number of theoretical studies, an analytical solution for the magnetically induced transmembrane potential change is still unavailable. In addition, although several studies have analyzed the impact of stimulation parameters, including stimulation intensity and frequency, as well as coil design and position, on the amount of tissue polarization, the effects of tissue non-homogeneity on cell polarization have not been fully elucidated. In this study, we have derived an analytical expression for the transmembrane potential induced by a low-frequency magnetic field in a spherical neuronal structure. This model is representative of a spherical cell body or any neuronal structure of a similar shape. The model cell is located in an extracellular medium and possesses a low-conductive membrane and an internal cytoplasm. These three regions represent the basic tissue non-homogeneity of a neuron at a microscopic level. The sensitivity of the induced transmembrane potential to the coil position and to the geometrical and electrical parameters of the model structure was studied in a broad physiologically relevant range. Our results demonstrate that the structure is regionally polarized, with the pattern of polarization depending on the relative positioning between the model cell and the stimulation coil. In addition, both the geometrical and electrical parameters of the structure affect the amount of polarization. These results may be generalized to other neuronal tissues that possess similar non-homogenous properties, but different shapes, such as an axon. Our results support the idea that aside from coil design and position, tissue non-homogeneity could play an important role in determining the effects of magnetic stimulation.
随时间变化的磁场可在神经组织中感应出电场,这一现象最近已在诸如外周神经刺激和经颅磁刺激等临床应用中得到探索。尽管在直接电刺激过程中感应出的跨膜电位已成为众多理论研究的主题,但磁诱导跨膜电位变化的解析解仍然无法获得。此外,尽管有几项研究分析了刺激参数(包括刺激强度和频率)以及线圈设计和位置对组织极化量的影响,但组织非均匀性对细胞极化的影响尚未得到充分阐明。在本研究中,我们推导了低频磁场在球形神经元结构中感应出的跨膜电位的解析表达式。该模型代表球形细胞体或任何类似形状的神经元结构。模型细胞位于细胞外介质中,具有低导电性的膜和内部细胞质。这三个区域代表了微观层面神经元的基本组织非均匀性。在广泛的生理相关范围内研究了感应跨膜电位对线圈位置以及模型结构的几何和电学参数的敏感性。我们的结果表明,该结构会发生区域极化,极化模式取决于模型细胞与刺激线圈之间的相对位置。此外,结构的几何和电学参数都会影响极化量。这些结果可能推广到具有类似非均匀特性但形状不同的其他神经组织,如轴突。我们的结果支持这样一种观点,即除了线圈设计和位置外,组织非均匀性在确定磁刺激效果方面可能起着重要作用。
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