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成人峡部裂性腰椎滑脱的后路腰椎椎间融合术与后外侧融合术的比较

Posterior lumbar interbody fusion versus posterolateral fusion in adult isthmic spondylolisthesis.

作者信息

Ekman Per, Möller Hans, Tullberg Tycho, Neumann Pavel, Hedlund Rune

机构信息

Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden.

出版信息

Spine (Phila Pa 1976). 2007 Sep 15;32(20):2178-83. doi: 10.1097/BRS.0b013e31814b1bd8.

Abstract

STUDY DESIGN

A prospective study with historical controls.

OBJECTIVE

To compare the outcome of posterior lumbar interbody fusion (PLIF) and posterolateral fusion (PLF) in adult isthmic spondylolisthesis.

SUMMARY OF BACKGROUND DATA

On theoretical grounds, PLIF has been suggested to result in an improved outcome compared with PLF. Data to support this view, however, are lacking.

METHODS

A total of 86 patients (age range, 18-55 years) with adult isthmic spondylolisthesis were operated on with PLIF. The comparison group consisted of 77 patients operated on with PLF with iliac bone autograft, 40 with and 37 without pedicle fixation. The 2 groups had similar socioeconomic, age and sex distribution, level of pain, and disability. Inclusion criteria and outcome measurements were identical in both groups. The PLIF group was operated on with autograft and carbon fiber ramps with pedicle fixation. Before surgery and at the 2-year follow-up, pain (VAS) and functional disability were quantified by the Disability Rating Index (DRI, 0-100) and the Oswestry Disability Index (ODI). The global outcome was assessed by the patient as much better, better, unchanged, or worse.

RESULTS

The follow-up rate was 98% in the PLIF group and 97% in the PLF group. In PLIF patients, pain index improved from 66 to 35 (P < 0.0001) and the DRI from 47 to 30 (P < 0.01). The levels of pain and DRI were similar to that of the PLF group (pain 37, DRI 29, not significant), and the ODI was identical in both groups (25); 74% of the patients in both groups classified the results as much better or better.

CONCLUSION

Type of fusion, PLIF or PLF, does not affect the 2-year outcome of surgical treatment of adult isthmic spondylolisthesis. Despite the theoretical advantages of PLIF, no improvement on patient outcome compared with posterolateral fusion could be demonstrated, questioning the need of anterior support in short lumbar fusions.

摘要

研究设计

一项采用历史对照的前瞻性研究。

目的

比较成人峡部裂性腰椎滑脱症行后路腰椎椎间融合术(PLIF)和后外侧融合术(PLF)的疗效。

背景数据总结

从理论上讲,与PLF相比,PLIF被认为能带来更好的疗效。然而,缺乏支持这一观点的数据。

方法

共86例(年龄范围18 - 55岁)成人峡部裂性腰椎滑脱症患者接受了PLIF手术。对照组由77例行PLF并自体髂骨移植的患者组成,其中40例使用椎弓根固定,37例未使用。两组在社会经济状况、年龄、性别分布、疼痛程度和残疾程度方面相似。两组的纳入标准和疗效评估指标相同。PLIF组采用自体骨移植和带椎弓根固定的碳纤维斜撑进行手术。术前及术后2年随访时,通过残疾评定指数(DRI,0 - 100)和Oswestry残疾指数(ODI)对疼痛(视觉模拟评分法,VAS)和功能残疾进行量化。患者对总体疗效的评价为明显改善、改善、无变化或恶化。

结果

PLIF组的随访率为98%,PLF组为97%。PLIF患者的疼痛指数从66改善至35(P < 0.0001),DRI从47改善至30(P < 0.01)。疼痛水平和DRI与PLF组相似(疼痛37,DRI 29,无显著差异),两组的ODI相同(25);两组中74%的患者将结果评为明显改善或改善。

结论

融合方式,PLIF或PLF,不影响成人峡部裂性腰椎滑脱症手术治疗的2年疗效。尽管PLIF有理论上的优势,但与后外侧融合术相比,未显示出患者疗效有改善,这对短节段腰椎融合术中前路支撑的必要性提出了质疑。

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