Salminen H, Sääf M, Ringertz H, Strender L E
Centre for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden.
Osteoporos Int. 2008 Feb;19(2):201-9. doi: 10.1007/s00198-007-0463-4. Epub 2007 Sep 14.
IGFBP-1 showed a strong inverse relation to the BMD values. The IGF-I values had a significant positive relation to the BMD values at all sites with the exception of the lumbar spine. The use of loop diuretics was a more important cause of secondary hyperparathyroidism than vitamin D status.
Our aim was to investigate among elderly women the relationship to osteoporosis of calcium-regulating hormones and insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-1 (IGFBP-1).
A population-based cross-sectional study of 350 elderly women (mean age 73 years). Measurements of bone mineral density (BMD) of the left hip, lumbar spine and heel and risk markers for osteoporosis were studied.
The BMD values showed significant inverse relationship with the values of IGFBP-1 at all sites of measurement and significant positive relationship with the values of IGF-I at all sites with the exception of the lumbar spine. There was no significant association between the values of BMD and the values of 25-hydroxy vitamin D (25(OH)D). The use of loop diuretics was strongly and significantly associated with elevated levels of PTH >65 pg/ml (OR 4.4, P < 0.001).
The anabolic growth factor IGF-I and its modulating binding protein IGFBP-1 showed a stronger association with the BMD values than the calcium regulating hormones 25(OH)D and PTH. In this study the use of loop diuretics was a more important cause of secondary hyperparathyroidism than vitamin D status.
胰岛素样生长因子结合蛋白-1（IGFBP-1）与骨密度值呈强烈负相关。除腰椎外，胰岛素样生长因子-I（IGF-I）值与所有部位的骨密度值均呈显著正相关。袢利尿剂的使用是继发性甲状旁腺功能亢进比维生素D状态更重要的原因。
我们的目的是在老年女性中研究钙调节激素、胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子结合蛋白-1（IGFBP-1）与骨质疏松症的关系。
对350名老年女性（平均年龄73岁）进行基于人群的横断面研究。研究了左髋、腰椎和足跟的骨密度（BMD）测量值以及骨质疏松症的风险标志物。
骨密度值在所有测量部位与IGFBP-1值呈显著负相关，除腰椎外，在所有部位与IGF-I值呈显著正相关。骨密度值与25-羟基维生素D（25(OH)D）值之间无显著关联。袢利尿剂的使用与甲状旁腺激素水平>65 pg/ml升高密切相关（比值比4.4，P<0.001）。
合成代谢生长因子IGF-I及其调节结合蛋白IGFBP-1与骨密度值的关联比钙调节激素25(OH)D和甲状旁腺激素更强。在本研究中，袢利尿剂的使用是继发性甲状旁腺功能亢进比维生素D状态更重要的原因。
