Oscar-Berman Marlene, Marinković Ksenija
Department of Anatomy and Neurobiology, Boston University School of Medicine, L-815, 715 Albany Street, Boston, MA 02118, USA.
Neuropsychol Rev. 2007 Sep;17(3):239-57. doi: 10.1007/s11065-007-9038-6.
Alcoholism results from an interplay between genetic and environmental factors, and is linked to brain defects and associated cognitive, emotional, and behavioral impairments. A confluence of findings from neuroimaging, physiological, neuropathological, and neuropsychological studies of alcoholics indicate that the frontal lobes, limbic system, and cerebellum are particularly vulnerable to damage and dysfunction. An integrative approach employing a variety of neuroscientific technologies is essential for recognizing the interconnectivity of the different functional systems affected by alcoholism. In that way, relevant experimental techniques can be applied to assist in determining the degree to which abstinence and treatment contribute to the reversal of atrophy and dysfunction.
酒精中毒是由遗传和环境因素相互作用导致的，与大脑缺陷以及相关的认知、情感和行为障碍有关。对酗酒者进行神经影像学、生理学、神经病理学和神经心理学研究的一系列结果表明，额叶、边缘系统和小脑特别容易受到损伤和功能障碍的影响。采用多种神经科学技术的综合方法对于认识受酒精中毒影响的不同功能系统的相互关联性至关重要。通过这种方式，可以应用相关实验技术来帮助确定戒酒和治疗对萎缩和功能障碍逆转的贡献程度。
