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Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies.金黄色葡萄球菌对氟喹诺酮类和香豆素类药物耐药性的出现与维持：体外研究预测
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Genetic basis of resistance to fusidic acid in staphylococci.葡萄球菌对夫西地酸耐药性的遗传基础。
Antimicrob Agents Chemother. 2007 May;51(5):1737-40. doi: 10.1128/AAC.01542-06. Epub 2007 Feb 26.
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Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection.腐生葡萄球菌全基因组序列揭示了单纯性尿路感染的发病机制。
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13272-7. doi: 10.1073/pnas.0502950102. Epub 2005 Aug 31.
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Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus.gyrB和parE基因中突变的积累与金黄色葡萄球菌对新生霉素的高水平耐药性相关。
Antimicrob Agents Chemother. 2005 Sep;49(9):3810-5. doi: 10.1128/AAC.49.9.3810-3815.2005.
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Who are you--Staphylococcus saprophyticus?你是谁——腐生葡萄球菌？
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sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.σB调节毒力决定因素的表达和应激抗性：源自金黄色葡萄球菌8325-4的功能性rsbU菌株的特性分析
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腐生葡萄球菌对新生霉素的固有耐药性。

Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

作者信息

Vickers Anna A, Chopra Ian, O'Neill Alex J

机构信息

Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2007 Dec;51(12):4484-5. doi: 10.1128/AAC.00708-07. Epub 2007 Sep 17.

DOI:10.1128/AAC.00708-07
PMID:17876001
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2167987/
Abstract

Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

摘要

腐生葡萄球菌对新生霉素的内在抗性与药物靶蛋白（GyrB）的耐新生霉素形式的表达有关。定点诱变表明，抗性取决于GyrB中两个特定氨基酸残基的存在：第85位的甘氨酸和第140位的赖氨酸。