腐生葡萄球菌对新生霉素的固有耐药性。
Intrinsic novobiocin resistance in Staphylococcus saprophyticus.
作者信息
Vickers Anna A, Chopra Ian, O'Neill Alex J
机构信息
Antimicrobial Research Centre and Research Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2007 Dec;51(12):4484-5. doi: 10.1128/AAC.00708-07. Epub 2007 Sep 17.
Abstract
Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.
摘要
腐生葡萄球菌对新生霉素的内在抗性与药物靶蛋白（GyrB）的耐新生霉素形式的表达有关。定点诱变表明，抗性取决于GyrB中两个特定氨基酸残基的存在：第85位的甘氨酸和第140位的赖氨酸。
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